Neurodevelopmental disorders such as Fragile X Syndrome (FXS) and Autism Spectrum Disorder (ASD) are characterized by disrupted cortical oscillatory activity, particularly in the alpha and gamma frequency bands. These abnormalities are linked to deficits in attention, sensory processing, and cognitive function. In this work, we present an adaptive machine learning-based brain-computer interface (BCI) system designed to modulate neural oscillations through frequency-specific auditory stimulation to enhance cognitive readiness in individuals with FXS. EEG data were recorded from 38 participants using a 128-channel system under a stimulation paradigm consisting of a 30-second baseline (no stimulus) followed by 60-second auditory entrainment episodes at 7Hz, 9Hz, 11Hz, and 13Hz. A comprehensive analysis of power spectral features (Alpha, Gamma, Delta, Theta, Beta) and cross-frequency coupling metrics (Alpha-Gamma, Alpha-Beta, etc.) was conducted. The results identified Peak Alpha Power, Peak Gamma Power, and Alpha Power per second per channel as the most discriminative biomarkers. The 13Hz stimulation condition consistently elicited a significant increase in Alpha activity and suppression of Gamma activity, aligning with our optimization objective. A supervised machine learning framework was developed to predict EEG responses and dynamically adjust stimulation parameters, enabling real-time, subject-specific adaptation. This work establishes a novel EEG-driven optimization framework for cognitive neuromodulation, providing a foundational model for next-generation AI-integrated BCI systems aimed at personalized neurorehabilitation in FXS and related disorders.

Metabolic disorders, particularly type 2 diabetes mellitus (T2DM), represent a significant global health burden, disproportionately impacting genetically predisposed populations such as the Pima Indians (a Native American tribe from south central Arizona). This study introduces a novel machine learning (ML) framework that integrates predictive modeling with gene-agnostic pathway mapping to identify high-risk individuals and uncover potential therapeutic targets. Using the Pima Indian dataset, logistic regression and t-tests were applied to identify key predictors of T2DM, yielding an overall model accuracy of 78.43%. To bridge predictive analytics with biological relevance, we developed a pathway mapping strategy that links identified predictors to critical signaling networks, including insulin signaling, AMPK, and PPAR pathways. This approach provides mechanistic insights without requiring direct molecular data. Building upon these connections, we propose therapeutic strategies such as dual GLP-1/GIP receptor agonists, AMPK activators, SIRT1 modulators, and phytochemical, further validated through pathway enrichment analyses. Overall, this framework advances precision medicine by offering interpretable and scalable solutions for early detection and targeted intervention in metabolic disorders. The key contributions of this work are: (1) development of an ML framework combining logistic regression and principal component analysis (PCA) for T2DM risk prediction; (2) introduction of a gene-agnostic pathway mapping approach to generate mechanistic insights; and (3) identification of novel therapeutic strategies tailored for high-risk populations.

Personal use of this material is permitted. This work has been accepted for publication in the proceedings of the 2025 Advances in Science and Engineering Technology International Conferences (ASET). Zaheeruddin Ahmed Department of Computer Science & Engineering Manipal Academy of Higher Education Dubai, UAE zaheeruddin@manipaldubai.com Abstract -- Audio - based equipment condition monitoring suffers from a lack of standardized methodologies for algorithm selection, hindering reproducible research. Leveraging a rich 127 - feature set across time, frequency, and time - frequency domains, our methodology is validated on both synthetic and real - world datasets. Results demonstrate that an ensemble method achieves superior performance (94.2% accuracy, 0.942 F1 - score), with statistical testing confirming its significant outperformance of individual algorithms by 8 - 15%.

Student mental health is an increasing concern in academic institutions, where stress can severely impact well-being and academic performance. Traditional assessment methods rely on subjective surveys and periodic evaluations, offering limited value for timely intervention. This paper introduces a context-aware machine learning framework for classifying student stress using two complementary survey-based datasets covering psychological, academic, environmental, and social factors. The framework follows a six-stage pipeline involving preprocessing, feature selection (SelectKBest, RFECV), dimensionality reduction (PCA), and training with six base classifiers: SVM, Random Forest, Gradient Boosting, XGBoost, AdaBoost, and Bagging. To enhance performance, we implement ensemble strategies, including hard voting, soft voting, weighted voting, and stacking. Our best models achieve 93.09% accuracy with weighted hard voting on the Student Stress Factors dataset and 99.53% with stacking on the Stress and Well-being dataset, surpassing previous benchmarks. These results highlight the potential of context-integrated, data-driven systems for early stress detection and underscore their applicability in real-world academic settings to support student well-being.

A critical stage in the evolving landscape of VLSI design is the design phase that is transformed into register-transfer level (RTL), which specifies system functionality through hardware description languages like Verilog. Generally, evaluating the quality of an RTL design demands full synthesis via electronic design automation (EDA) tool is time-consuming process that is not well-suited to rapid design iteration and optimization. Although recent breakthroughs in machine Learning (ML) have brought early prediction models, these methods usually do not provide robust and generalizable solutions with respect to a wide range of RTL designs. This paper proposes a pre-synthesis framework that makes early estimation of power, performance and area (PPA) metrics directly from the hardware description language (HDL) code making direct use of library files instead of toggle files. The proposed framework introduces a bit-level representation referred to as the simple operator graph (SOG), which uses single-bit operators to generate a generalized and flexible structure that closely mirrors the characteristics of post synthesis design. The proposed model bridges the RTL and post-synthesis design, which will help in precisely predicting key metrics. The proposed tree-based ML framework shows superior predictive performance PPA estimation. Validation is carried out on 147 distinct RTL designs. The proposed model with 147 different designs shows accuracy of 98%, 98%, and 90% for WNS, TNS and power, respectively, indicates significant accuracy improvements relative to state-of-the-art methods.

We present a composite machine learning framework to estimate posterior probability distributions of bulge-to-total light ratio, half-light radius, and flux for Active Galactic Nucleus (AGN) host galaxies within $z<1.4$ and $m<23$ in the Hyper Supreme-Cam Wide survey. We divide the data into five redshift bins: low ($0

This study presents a machine learning framework for assessing similarity between audio content and predicting sentiment score. We construct a dataset containing audio samples from music covers on YouTube along with the audio of the original song, and sentiment scores derived from user comments, serving as proxy labels for content quality. Our approach involves extensive pre-processing, segmenting audio signals into 30-second windows, and extracting high-dimensional feature representations through Mel-Frequency Cepstral Coefficients (MFCC), Chroma, Spectral Contrast, and Temporal characteristics. Leveraging these features, we train regression models to predict sentiment scores on a 0-100 scale, achieving root mean square error (RMSE) values of 3.420, 5.482, 2.783, and 4.212, respectively. Improvements over a baseline model based on absolute difference metrics are observed. These results demonstrate the potential of machine learning to capture sentiment and similarity in audio, offering an adaptable framework for AI applications in media analysis.

Ever-increasing ubiquity of data and computational resources in the last decade have propelled a notable transition in the machine learning paradigm towards more distributed approaches. Such a transition seeks to not only tackle the scalability and resource distribution challenges but also to address pressing privacy and security concerns. To contribute to the ongoing discourse, this paper introduces Holonic Learning (HoL), a collaborative and privacy-focused learning framework designed for training deep learning models. By leveraging holonic concepts, the HoL framework establishes a structured self-similar hierarchy in the learning process, enabling more nuanced control over collaborations through the individual model aggregation approach of each holon, along with their intra-holon commitment and communication patterns. HoL, in its general form, provides extensive design and flexibility potentials. For empirical analysis and to demonstrate its effectiveness, this paper implements HoloAvg, a special variant of HoL that employs weighted averaging for model aggregation across all holons. The convergence of the proposed method is validated through experiments on both IID and Non-IID settings of the standard MNISt dataset. Furthermore, the performance behaviors of HoL are investigated under various holarchical designs and data distribution scenarios. The presented results affirm HoL's prowess in delivering competitive performance particularly, in the context of the Non-IID data distribution.

Power grids are moving towards 100% renewable energy source bulk power grids, and the overall dynamics of power system operations and electricity markets are changing. The electricity markets are not only dispatching resources economically but also taking into account various controllable actions like renewable curtailment, transmission congestion mitigation, and energy storage optimization to ensure grid reliability. As a result, price formations in electricity markets have become quite complex. Traditional root cause analysis and statistical approaches are rendered inapplicable to analyze and infer the main drivers behind price formation in the modern grid and markets with variable renewable energy (VRE). In this paper, we propose a machine learning-based analysis framework to deconstruct the primary drivers for price spike events in modern electricity markets with high renewable energy. The outcomes can be utilized for various critical aspects of market design, renewable dispatch and curtailment, operations, and cyber-security applications. The framework can be applied to any ISO or market data; however, in this paper, it is applied to open-source publicly available datasets from California Independent System Operator (CAISO) and ISO New England (ISO-NE).

Data analysis revolves around the central goal of aggregating metrics. The aggregation should be conducted in secret when the data points match personally identifiable information, such as the records or activities of specific users. Differential privacy (DP) is a method that restricts each data point's impact on the conclusion of the computation. Hence it has become the most frequently acknowledged approach to individual privacy. Although differentially private algorithms are theoretically possible, they are typically less efficient and accurate in practice than their non-private counterparts.